This is an entirely mouse-driven game with an emphasis on story. Each phase of research, think of them like levels, has objectives to complete. Completing those will move your research forward.
All things considered, Road of the Dead 2 plays much like a first-person action game. The only difference is that instead of moving on foot, you’re in a vehicle. As such, WASD controls the vehicle, and the mouse aims/fires. The space bar can be used to swerve the vehicle, and to interact with stops. You’ll see points of interest approaching as you drive toward them, and if you don’t brake quickly enough with S, then you’ll overshoot the stop and miss it entirely. Ultimately, the better you do, the more RP you’ll earn, and the more you can upgrade your characters and vehicle to allow you to survive for longer.